Tozadenant

Tozadenant

Tozadenant (SYN-115) is an adenosine A2A receptor antagonist.

SKU Unit Size PriceQuantity
HY-10995-10MG 10 mg $267.00 ex GST
HY-10995-50MG 50 mg $771.00 ex GST
Brand:
SKU: HY-10995 Category: Brand:

Product Description

Overview

  • Product Name: Tozadenant
  • CAS Number: 870070-55-6
  • Targets: Adenosine Receptor
  • Pathways: GPCR/G protein
  • Alternative Names: SYN-115;SYN115;SYN 115

Biological Activity

  • Tozadenant (SYN-115) is an adenosine A2A receptor antagonist. Treatment of Parkinson’s disease, dopaminergic neurotransmission disorders.
  • IC50:
  • Target: A2A receptor Tozadenant (SYN-115) is useful for treatment of post-traumatic stress disorder.

Chemical Information

  • M.Wt: 406.4991
  • Formula: C19H26N4O4S
  • Purity: 98-100% (actual purity reported on CofA)
  • Solubility: 10 mM in DMSO
  • Storage: As per the recommended conditions in the Certificate of Analysis.

References

[1] Lane S, et al. Cardiovascular and Subjective Effects of the Novel Adenosine A(2A) Receptor Antagonist SYN115 in Cocaine Dependent Individuals.J Addict Res Ther. 2012 Mar 28;S1. pii: 009.

[2] Black KJ, et al. Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease.J Neurosci. 2010 Dec 1;30(48):16284-92.

[3] Moeller FG, et al. Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A(2A) Antagonist in Cocaine Dependent Subjects.Front Psychiatry. 2012;3:44. Epub 2012 May 28.

[4] Hauser RA.Future treatments for Parkinson’s disease: surfing the PD pipeline.Int J Neurosci. 2011;121 Suppl 2:53-62.