Showing 1–12 of 109 results

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(3R
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(3R,4S)-Tofacitinib

$3,750.00

Tofacitinib (CP-690550) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

(3S
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(3S,4R)-Tofacitinib

$3,750.00

Tofacitinib (CP-690550 citrate) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

(3S
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(3S,4S)-Tofacitinib

$3,750.00

Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

AEE788
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AEE788

$183.00$967.00

AEE788 (NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKC? and CDK1.

Afatinib
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Afatinib

$85.00$225.00

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR (wt), EGFR (L858R), EGFR (L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

Afatinib (dimaleate)
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Afatinib (dimaleate)

$85.00$225.00

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR (wt), EGFR (L858R), EGFR (L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

AG 18
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AG 18

$85.00$316.00

AG-18 (RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 40 ?M.

AG-1478
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AG-1478

$85.00$365.00

AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

AG-490
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AG-490

$85.00$176.00

AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 ?M, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

Alantolactone
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Alantolactone

$113.00$178.00

Alantolactone (Alant camphor) is a sesquiterpene lactone; has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.

ARRY-380
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ARRY-380

$183.00$1,555.00

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.

AST-1306
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AST-1306

$260.00$1,185.00

AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.