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MI 2 Chemical Structure Picture
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MI 2

$152.00$1,146.00

MI 2 (MALT1 inhibitor) is an irreversible MALT1 protease inhibitor with an IC50 of 5.84 μM.

ML385 Chemical Structure Picture
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ML385

$110.00$1,937.00

ML385 is a novel and specific NRF2 inhibitor.

MLN120B Chemical Structure Picture
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MLN120B

$166.00$1,164.00

MLN120B is a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM.

Morusin Chemical Structure Picture
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Morusin

$102.00$552.00

Morusin is a prenylated flavonoid isolated from M. australis with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB activity.

MRT67307 Chemical Structure Picture
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MRT67307

$134.00$1,147.00

MRT67307 is a dual inhibitor of the IKKε and TBK-1, which mediates the phosphorylation of interferon regulatory factor 3 (IRF3), with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, and also targets ULK1 and ULK2 with high potency (IC50 values of 45 and 38 nM, respectively).

Naringin Dihydrochalcone Chemical Structure Picture
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Naringin Dihydrochalcone

$149.00$1,534.00

Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

Neferine Chemical Structure Picture
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Neferine

$79.00$407.00

Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.

Neochlorogenic acid Chemical Structure Picture
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Neochlorogenic acid

$207.00$327.00

Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

NG25 Chemical Structure Picture
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NG25

$134.00$632.00

NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.

NK-252 Chemical Structure Picture
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NK-252

$85.00$778.00

NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

Oxaprozin Chemical Structure Picture
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Oxaprozin

$72.00$207.00

Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

Parthenolide Chemical Structure Picture
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Parthenolide

$85.00$198.00

Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.