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BMS-345541 (free base) Chemical Structure Picture
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BMS-345541 (free base)

$169.00$1,035.00

BMS-345541 free base is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.

Brusatol Chemical Structure Picture
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Brusatol

$219.00$380.00

Brusatol, isolated from the Brucea javanica plant, inhibits Nrf2.

Caffeic acid phenethyl ester Chemical Structure Picture
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Caffeic acid phenethyl ester

$72.00$99.00

Caffeic acid phenethyl ester is a NF-κB inhibitor.

CBL0137 hydrochloride Chemical Structure Picture
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CBL0137 hydrochloride

$99.00$1,334.00

CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively.

CDDO-EA Chemical Structure Picture
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CDDO-EA

$568.00$3,386.00

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

CDDO-Im Chemical Structure Picture
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CDDO-Im

$214.00$310.00

CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ, also has anti-cancer and anti-inflammatory activities.

CID-2858522 Chemical Structure Picture
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CID-2858522

$95.00$166.00

CID-2858522 is a highly potent and selective antigen receptor-mediated NF-κB activation inhibitor with an IC50 of 70 nM.

Curcumin Chemical Structure Picture
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Curcumin

$85.00$134.00

Curcumin is a natural phenolic compound with impressive antioxidant properties, acts as a p300/CREB-binding protein inhibitor of histone acetyltransferase activity, and also activates nuclear factor (erythroid-2 related) factor 2 (Nrf2).

Cyclo(his-pro) Chemical Structure Picture
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Cyclo(his-pro)

$134.00$342.00

Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(His-Pro) could inhibit NF-κB nuclear accumulation.

Cynaropicrin Chemical Structure Picture
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Cynaropicrin

$568.00$810.00

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

Danshensu Chemical Structure Picture
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Danshensu

$85.00$246.00

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

DHMEQ (racemate) Chemical Structure Picture
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DHMEQ (racemate)

$456.00$907.00

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.