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TAK-285 Chemical Structure Picture
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TAK-285

$359.00$2,017.00

TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.

TCS PIM-1 1 Chemical Structure Picture
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TCS PIM-1 1

$180.00$761.00

TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).

TCS-PIM-1-4a Chemical Structure Picture
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TCS-PIM-1-4a

$102.00$769.00

TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK; kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM).

TG-101348 Chemical Structure Picture
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TG-101348

$134.00$810.00

TG-101348 is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3.

TG101209 Chemical Structure Picture
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TG101209

$117.00$729.00

TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.

Tofacitinib Chemical Structure Picture
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Tofacitinib

$85.00$456.00

Tofacitinib inhibits JAK3 with IC50 of 1 nM while inhibiting JAK2, JAK1, Rock-II and Lck with IC50 values of 20, 112, 3400 and 3870 nM, respectively.

Tofacitinib (citrate) Chemical Structure Picture
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Tofacitinib (citrate)

$85.00$456.00

Tofacitinib citrate inhibits JAK3 with IC50 of 1 nM while inhibiting JAK2, JAK1, Rock-II and Lck with IC50 values of 20 nM, 112 nM, 3,400 nM and 3,870 nM, respectively.

TP-3654 Chemical Structure Picture
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TP-3654

$149.00$1,357.00

TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

Trastuzumab Chemical Structure Picture
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Trastuzumab

$263.00$3,869.00

Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer.

TYK2-IN-2 Chemical Structure Picture
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TYK2-IN-2

$246.00$4,513.00

TYK2-IN-2 is an inhibitor of TYK2, used for treatment of inflammatory and autoimmune diseases.

Tyrphostin AG 528 Chemical Structure Picture
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Tyrphostin AG 528

$72.00$649.00

Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.

Tyrphostin AG 879 Chemical Structure Picture
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Tyrphostin AG 879

$102.00$681.00

TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 μmol/L) than EGFR (IC50 >500 μmol/L).