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(-)-Epigallocatechin Gallate Chemical Structure Picture
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(-)-Epigallocatechin Gallate

$72.00$92.00

(-)-Epigallocatechin Gallate is an antioxidant polyphenol flavonoid form green tea, and inhibits the activation of EGFR, HER2 and HER3, with antitumor activity.

(1S
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(1S,3R,5R)-PIM447 (dihydrochloride)

$230.00$2,420.00

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

(3R
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(3R,4S)-Tofacitinib

$4,030.00

(3R,4S)-Tofacitinib is an enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

(3S
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(3S,4R)-Tofacitinib

$4,030.00

(3S,4R)-Tofacitinib is an enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

(3S
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(3S,4S)-Tofacitinib

$4,030.00$4,432.00

(3S,4S)-Tofacitinib is the S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

(Z)-SMI-4a Chemical Structure Picture
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(Z)-SMI-4a

$93.00$435.00

(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested.

AEE788 Chemical Structure Picture
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AEE788

$198.00$1,100.00

AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.

Afatinib Chemical Structure Picture
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Afatinib

$85.00$310.00

Afatinib is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

Afatinib (dimaleate) Chemical Structure Picture
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Afatinib (dimaleate)

$85.00$310.00

Afatinib dimaleate is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

AG 18 Chemical Structure Picture
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AG 18

$85.00$351.00

AG 18 (RG-50810;Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

AG 555 Chemical Structure Picture
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AG 555

$85.00$890.00

AG 555 is an EGFR tyrosine kinase inhibitor.

AG-1478 Chemical Structure Picture
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AG-1478

$85.00$407.00

AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM.