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(+)-Apogossypol Chemical Structure Picture
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(+)-Apogossypol

$568.00$810.00

(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.

(2-Hydroxypropyl)-β-cyclodextrin Chemical Structure Picture
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(2-Hydroxypropyl)-β-cyclodextrin

$85.00$149.00

(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.

(E)-[6]-Dehydroparadol Chemical Structure Picture
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(E)-[6]-Dehydroparadol

$149.00$1,583.00

(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.

(S)-Gossypol (acetic acid) Chemical Structure Picture
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(S)-Gossypol (acetic acid)

$246.00$729.00

(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.

[6]-Gingerol Chemical Structure Picture
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[6]-Gingerol

$85.00$702.00

[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

10058-F4 Chemical Structure Picture
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10058-F4

$85.00$327.00

10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression.

10074-G5 Chemical Structure Picture
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10074-G5

$102.00$681.00

10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.

2-HBA Chemical Structure Picture
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2-HBA

$102.00$986.00

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid Chemical Structure Picture
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5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

$72.00$246.00

PK11007 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.

A-1155463 Chemical Structure Picture
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A-1155463

$230.00$1,856.00

A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.

A-1210477 Chemical Structure Picture
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A-1210477

$102.00$1,051.00

A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and >660 nM, respectively.

A-1331852 Chemical Structure Picture
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A-1331852

$198.00$1,776.00

A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.